0 Background and Rationale Functional Neurological Disorder (FND) represents a significant clinical challenge, characterized by neurological symptoms that are inconsistent with traditional neurological diseases. These symptoms can manifest as motor or sensory disturbances, seizures, or other neurological dysfunctions. The conventional treatment approaches, which often include psychotherapy and physiotherapy, can yield varying results, leading to a…
4 Understanding Functional Neurological Disorder Functional Neurological Disorder (FND) presents a complex challenge for both patients and clinicians. It involves a range of neurological symptoms—including motor disabilities, sensory alterations, and non-epileptic seizures—without a clear structural or biochemical cause in the brain. This means that while symptoms are real and can be debilitating, they do not…
3 Study Overview The SaVeBRAIN.Kids initiative is a comprehensive research project focused on addressing the significant challenge of mild traumatic brain injury (mTBI) among children in Germany. This study employs a cluster-randomized stepped-wedge trial design, a method that allows for progressive implementation and assessment of interventions across various groups over time. Through this approach, the…
1 Study Overview This research explores the effects of repeated mild traumatic brain injuries (mTBIs) on neuroinflammation and cognitive deficits, employing a unique model designed to replicate the complexities of these injuries in a controlled environment. The aim is to deepen our understanding of the persistent effects paralleled in human cases following similar injuries, including…
1 Traumatic Microbleeds Characteristics Traumatic microbleeds (TMBs) are small, focal areas of hemorrhage within the brain that are primarily a consequence of minor traumatic brain injury (mTBI). Although they can be challenging to detect without advanced imaging techniques, their identification is critical as they can elucidate the underlying pathophysiological changes occurring in the brain after…
1 Study Overview The research aimed to explore the preferences of individuals diagnosed with sleep apnoea regarding various treatment options available in Australia. Sleep apnoea, a condition characterized by repeated interruptions in breathing during sleep, can lead to numerous health complications if left untreated. Treatments vary widely, from lifestyle modifications and oral devices to continuous…
0 Study Overview Electroconvulsive therapy (ECT) has been a significant intervention in the treatment of severe mental health conditions, particularly major depressive disorder and treatment-resistant bipolar disorder. Its application dates back several decades, and while it is often effective, it has raised concerns regarding potential long-term cognitive effects, notably dementia risk. This systematic review and…
0 Study Overview This research delves into the relationship between cognitive performance variability and white matter organization in individuals who have experienced chronic mild traumatic brain injury (TBI). Chronic mild TBI, often associated with common forms of head trauma, can lead to persistent cognitive difficulties that are not always correlated with the initial severity of…
6 Study Overview This research focused on assessing the effectiveness of a targeted intervention aimed at enhancing emotion regulation in individuals who have suffered from traumatic brain injuries (TBIs). Recognizing that emotional dysregulation is a common consequence of TBIs, the study aimed to investigate whether a structured program could lead to observable improvements in emotional…
6 Study Overview This research examines the impact of engineered rotational acceleration on axonal injury in adult ferrets, utilizing a closed head impact model to simulate conditions analogous to traumatic brain injuries often seen in humans. The study aims to elucidate the progression and characteristics of axonal damage following such impacts, contributing to a greater…